SIJ1777

SIJ1777 is a GNF-7 (HY-10943) derivative, possesses potent anti-cancer effects on melanoma cells harboring BRAF class I/II/III mutations. SIJ1777 substantially inhibits the activation of MEK, ERK, and AKT. SIJ1777 remarkably induces apoptosis and significantly blocks migration, invasion, and anchorage-independent growth of melanoma cells harboring BRAF class I/II/II mutations[1].

Product Specifications

CAS Number

[839707-55-0]

UNSPSC

12352005

Target

Akt; Apoptosis; ERK; MEK

Type

Reference compound

Related Pathways

Apoptosis; MAPK/ERK Pathway; PI3K/Akt/mTOR; Stem Cell/Wnt

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/sij1777.html

Smiles

O=C(NC1=CC=C(C)C(N2CC3=CN=C(NC4=NN(C)C=C4)N=C3N(C)C2=O)=C1)C5=CC=CC(C(F)(F)F)=C5

Molecular Formula

C26H23F3N8O2

Molecular Weight

536.51

References & Citations

[1]Kim N, et al. Novel and Potent Small Molecules against Melanoma Harboring BRAF Class I/II/III Mutants for Overcoming Drug Resistance. Int J Mol Sci. 2021 Apr 6;22 (7) :3783.