SIJ1777
Product Specifications
UNSPSC Description
SIJ1777 is a GNF-7 (HY-10943) derivative, possesses potent anti-cancer effects on melanoma cells harboring BRAF class I/II/III mutations. SIJ1777 substantially inhibits the activation of MEK, ERK, and AKT. SIJ1777 remarkably induces apoptosis and significantly blocks migration, invasion, and anchorage-independent growth of melanoma cells harboring BRAF class I/II/II mutations[1].
Target Antigen
Akt; Apoptosis; ERK; MEK
Type
Reference compound
Related Pathways
Apoptosis;MAPK/ERK Pathway;PI3K/Akt/mTOR;Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/sij1777.html
Smiles
O=C(NC1=CC=C(C)C(N2CC3=CN=C(NC4=NN(C)C=C4)N=C3N(C)C2=O)=C1)C5=CC=CC(C(F)(F)F)=C5
Molecular Weight
536.51
References & Citations
[1]Kim N, et al. Novel and Potent Small Molecules against Melanoma Harboring BRAF Class I/II/III Mutants for Overcoming Drug Resistance. Int J Mol Sci. 2021 Apr 6;22(7):3783.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-164400/SIJ1777-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-164400/
Clinical Information
No Development Reported
CAS Number
839707-55-0
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