SIJ1777
SIJ1777 is a GNF-7 (HY-10943) derivative, possesses potent anti-cancer effects on melanoma cells harboring BRAF class I/II/III mutations. SIJ1777 substantially inhibits the activation of MEK, ERK, and AKT. SIJ1777 remarkably induces apoptosis and significantly blocks migration, invasion, and anchorage-independent growth of melanoma cells harboring BRAF class I/II/II mutations[1].
Product Specifications
CAS Number
[839707-55-0]
UNSPSC
12352005
Target
Akt; Apoptosis; ERK; MEK
Type
Reference compound
Related Pathways
Apoptosis; MAPK/ERK Pathway; PI3K/Akt/mTOR; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/sij1777.html
Smiles
O=C(NC1=CC=C(C)C(N2CC3=CN=C(NC4=NN(C)C=C4)N=C3N(C)C2=O)=C1)C5=CC=CC(C(F)(F)F)=C5
Molecular Formula
C26H23F3N8O2
Molecular Weight
536.51
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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