Theophylline-d6

Theophylline-d6 is the deuterium labeled Theophylline. Theophylline is a nonselective phosphodiesterase (PDE) inhibitor, adenosine receptor blocker, and histone deacetylase (HDAC) activator.

Product Specifications

CAS Number

[117490-39-8]

Product Name Alternative

1,3-Dimethylxanthine-d6; Theo-24-d6

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Adenosine Receptor; Autophagy; Endogenous Metabolite; Phosphodiesterase (PDE)

Type

Isotope-Labeled Compounds

Related Pathways

Autophagy; GPCR/G Protein; Metabolic Enzyme/Protease

Field of Research

Cancer

Purity

99.30

Solubility

10 mM in DMSO|DMF : ≥ 10mg/mL|DMSO : ≥ 10mg/mL|Ethanol : ≥ 1mg/mL

Smiles

O=C(N1C([2H])([2H])[2H])N(C([2H])([2H])[2H])C2=C(N=CN2)C1=O

Molecular Formula

C7H2D6N4O2

Molecular Weight

186.20

Precautions

H302, H315, H319, H335

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Deree J, et al. Insights into the regulation of TNF-alpha production in human mononuclear cells: the effects of non-specific phosphodiesterase inhibition. Clinics (Sao Paulo) . 2008 Jun;63 (3) :321-8.|[3]Marques LJ, et al. Pentoxifylline inhibits TNF-alpha production from human alveolar macrophages. Am J Respir Crit Care Med. 1999 Feb;159 (2) :508-11.|[4]Daly JW, et al. Adenosine receptors: development of selective agonists and antagonists. Prog Clin Biol Res. 1987;230:41-63.