Benzethonium (chloride)

Benzethonium chloride inhibits nicotinic acetylcholine receptors in human recombinant α7 and α4β2 neurons in Xenopus laevis oocytes, which has antibacterial, anticancer, antisepsis and disinfection activity. Benzethonium chloride induced Apoptosis and activated caspases in cancer cell lines. Benzethonium chloride ablates the tumor-forming ability of FaDu cells, delays the growth of xenograft tumors in vivo[1][2][3].

Product Specifications

CAS Number

[121-54-0]

UNSPSC

12352005

Hazard Statement

H301, H314, H400, H410

Target

Apoptosis; Bacterial; Caspase; nAChR

Type

Reference compound

Related Pathways

Anti-infection; Apoptosis; Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Cancer; Infection; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/Benzethonium-chloride.html

Purity

98.47

Solubility

DMSO : 33.33 mg/mL (ultrasonic) |H2O : 20 mg/mL (ultrasonic)

Smiles

CC(C)(C)CC(C1=CC=C(OCCOCC[N+](C)(C)CC2=CC=CC=C2)C=C1)(C)C.[Cl-]

Molecular Formula

C27H42ClNO2

Molecular Weight

448.08

Precautions

H301, H314, H400, H410

References & Citations

[1]Maillard JY. Impact of benzalkonium chloride, benzethonium chloride and chloroxylenol on bacterial antimicrobial resistance. J Appl Microbiol. 2022 Dec;133 (6) :3322-3346.|[2]Yip KW, et al. Benzethonium chloride: a novel anticancer agent identified by using a cell-based small-molecule screen. Clin Cancer Res. 2006 Sep 15;12 (18) :5557-69. |[3]Sreevidya VS, et al. Benzalkonium chloride, benzethonium chloride, and chloroxylenol - Three replacement antimicrobials are more toxic than triclosan and triclocarban in two model organisms. Environ Pollut. 2018 Apr;235:814-824.