Mogroside III

Mogroside III is a triterpenoid glycoside. Mogroside III exhibits maltase inhibitory effect with an IC50 value of 1.6 mM. Mogroside III enhances oocyte developmental potential by promoting autophagy in cumulus cells. Mogroside III, as the active ingredient of the low-polarity glycoside component (L-SGgly), L-SGgly can increase serum GLP-1 levels, improve insulin resistance, and reduce IL-6 levels, and has hypoglycemic, lipid-regulating and anti-inflammatory effects. Mogroside III can be used for the studies of type 2 diabetes mellitus (T2DM) and assisted reproductive technology[1][2][3].

Product Specifications

CAS Number

[130567-83-8]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Autophagy; Glycosidase

Type

Natural Products

Related Pathways

Autophagy; Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Endocrinology; Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/mogroside-iii.html

Purity

99.88

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)

Smiles

C[C@@]([C@@](CC[C@H](O[C@]([C@@H]([C@@H](O)[C@@H]1O)O)([H])O[C@@H]1CO)C2(C)C)([H])C2=CC3)([C@@H](C[C@@]45C)O)[C@]3([H])[C@@]4(CC[C@]5([H])[C@H](C)CC[C@H](C(C)(O)C)O[C@@H]([C@@H]([C@@H](O)[C@@H]6O)O)O[C@@H]6CO[C@@H]([C@@H]([C@@H](O)[C@@H]7O)O)O[C@@H]7CO)C

Molecular Formula

C48H82O19

Molecular Weight

963.15

Precautions

H302, H315, H319, H335

References & Citations

[1]Tian X, et al. Mogroside III improves bovine oocyte in vitro maturation by regulating autophagy in cumulus cells. Theriogenology. 2025 Apr 15;237:1-12. |[2]Zhang Y, et al. Anti-hyperglycemic and anti-hyperlipidemic effects of a special fraction of Luohanguo extract on obese T2DM rats. J Ethnopharmacol. 2020 Jan 30;247:112273.|[3]Suzuki YA, et al. Triterpene glycosides of Siraitia grosvenori inhibit rat intestinal maltase and suppress the rise in blood glucose level after a single oral administration of maltose in rats. J Agric Food Chem. 2005 Apr 20;53 (8) :2941-6.