1-Stearoyl-2-arachidonoyl-sn-glycerol

1-Stearoyl-2-arachidonoyl-sn-glycerol is a diacylglycerol (DAG) containing polyunsaturated fatty acids. 1-Stearoyl-2-arachidonoyl-sn-glycerol can activate PKC. 1-Stearoyl-2-arachidonoyl-sn-glycerol also can augment nonselective cation channel (NSCC) activity[1][2].

Product Specifications

CAS Number

[65914-84-3]

UNSPSC

12352211

Hazard Statement

H225, H319, H336

Target

Endogenous Metabolite; PKC; TRP Channel

Type

Reference compound

Related Pathways

Epigenetics; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling; TGF-beta/Smad

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/1-stearoyl-2-arachidonoyl-sn-glycerol.html

Concentration

15.50 mM * 1 mL in Methyl acetate

Purity

99.0

Solubility

10 mM in DMSO

Smiles

CCCCC/C=C\C/C=C\C/C=C\C/C=C\CCCC(O[C@@H](CO)COC(CCCCCCCCCCCCCCCCC)=O)=O

Molecular Formula

C41H72O5

Molecular Weight

645.01

Precautions

H225, H319, H336

References & Citations

[1]Song T, et, al. Inositol 1,4,5-trisphosphate activates TRPC3 channels to cause extracellular Ca2+ influx in airway smooth muscle cells. Am J Physiol Lung Cell Mol Physiol. 2015 Dec 15;309 (12) :L1455-66.|[2]Madani S, et, al. Implication of acyl chain of diacylglycerols in activation of different isoforms of protein kinase C. FASEB J. 2001 Dec;15 (14) :2595-601.|[3]Glasmacher S, et, al. Characterization of pepcan-23 as pro-peptide of RVD-hemopressin (pepcan-12) and stability of hemopressins in mice. Adv Biol Regul. 2021 May;80:100808.