MYCi361

MYCi361 (NUCC-0196361) is a MYC inhibitor with the Kd of 3.2 μM for binding to MYC. MYCi361 (NUCC-0196361) suppresses tumor growth and enhances anti-PD1 immunotherapy[1].

Product Specifications

CAS Number

[2289690-31-7]

Product Name Alternative

NUCC-0196361

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

C-Myc

Type

Reference compound

Related Pathways

Apoptosis

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/myci361.html

Purity

99.95

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

ClC1=CC=C(COC2=CC=C(C3=CC(C(F)(F)F)=NN3C)C(O)=C2C4=CC(C(F)(F)F)=CC(C(F)(F)F)=C4)C=C1

Molecular Formula

C26H16ClF9N2O2

Molecular Weight

594.86

Precautions

H302, H315, H319, H335

References & Citations

[1]Han H, et al. Small-Molecule MYC Inhibitors Suppress Tumor Growth and Enhance Immunotherapy. Cancer Cell. 2019 Nov 11;36 (5) :483-497.e15.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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