Miravirsen (sodium)
Miravirsen sodium is a potent miR-122 inhibitor and inhibits the biogenesis of miR-122. Miravirsen sodium is a 15-nucleotide locked nucleic acid-modified phosphorothioate antisense oligonucleotide. Miravirsen sodium inhibits HCV replication, and can be used in research of HCV infection[1][2].
Product Specifications
Product Name Alternative
SPC-3649 (sodium)
UNSPSC
12352208
Target
MicroRNA
Type
Oligonucleotides
Related Pathways
Epigenetics
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/miravirsen-sodium.html
Purity
99.44
Solubility
10 mM in H2O
Smiles
[Miravirsen(sodium)]
Molecular Weight
4967 (free acid)
References & Citations
[1]Luca F R Gebert, et al. Miravirsen (SPC3649) can inhibit the biogenesis of miR-122. Nucleic Acids Res. 2014 Jan;42 (1) :609-21.|[2]Elmén J, et, al. Antagonism of microRNA-122 in mice by systemically administered LNA-antimiR leads to up-regulation of a large set of predicted target mRNAs in the liver. Nucleic Acids Res. 2008 Mar;36 (4) :1153-62.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, stored under nitrogen, away from moisture)
Scientific Category
Oligonucleotides
Clinical Information
Phase 2
Available Sizes
Curated Selection
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