Roniciclib
Roniciclib is an orally bioavailable pan-cyclin dependent kinase (CDK) inhibitor, with IC50s of 5-25 nM for CDK1, CDK2, CDK3, CDK4, CDK7 and CDK9.
Product Specifications
CAS Number
1223498-69-8
Product Name Alternative
BAY 1000394
UNSPSC
12352005
Target
CDK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Roniciclib.html
Purity
98.09
Solubility
DMSO : ≥ 250 mg/mL
Smiles
C[C@@H](O)[C@H](OC1=NC(NC2=CC=C([S@@](=N)(C3CC3)=O)C=C2)=NC=C1C(F)(F)F)C
Molecular Formula
C18H21F3N4O3S
Molecular Weight
430.44
References & Citations
[1]Siemeister G, et al. BAY 1000394, a novel cyclin-dependent kinase inhibitor, with potent antitumor activity in mono- and in combination treatment upon oral application. Mol Cancer Ther. 2012 Oct;11 (10) :2265-73.|[2]Lücking U, et al. The lab oddity prevails: discovery of pan-CDK inhibitor (R) -S-cyclopropyl-S- (4-{[4-{[ (1R,2R) -2-hydroxy-1-methylpropyl]oxy}-5- (trifluoromethyl) pyrimidin-2-yl]amino}phenyl) sulfoximide (BAY 1000394) for the treatment of cancer. ChemMedChem. 2013 Jul;8 (7) :1067-85.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
CDK1; CDK2; CDK4; CDK7; CDK9
Available Sizes
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