A-205804

A-205804 is an orally bioavailable, potent and selective lead inhibitor of E-selectin and ICAM-1 expression, with an IC50 of 20 nM and 25 nM for E-selectin and ICAM-1, respectively. A-205804 can be used in the research of chronic inflammatory diseases[1].

Product Specifications

CAS Number

[251992-66-2]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Integrin

Type

Reference compound

Related Pathways

Cytoskeleton

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/a-205804.html

Concentration

10mM

Purity

98.96

Solubility

DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(C(S1)=CC2=C1C=NC=C2SC3=CC=C(C)C=C3)N

Molecular Formula

C15H12N2OS2

Molecular Weight

300.41

Precautions

H302, H315, H319, H335

References & Citations

[1]Stewart AO, et al. Discovery of inhibitors of cell adhesion molecule expression in human endothelial cells. 1. Selective inhibition of ICAM-1 and E-selectin expression. J Med Chem. 2001 Mar 15;44 (6) :988-1002.|[2]Morita K, et al. RUNX transcription factors potentially control E-selectin expression in the bone marrow vascular niche in mice. Blood Adv. 2018 Mar 13;2 (5) :509-515.