Zasocitinib

Zasocitinib (NDI-034858) is a TYK2 inhibitor, target TYK2 JH2 domain with binding constant Kd of [1].

Product Specifications

CAS Number

[2272904-53-5]

Product Name Alternative

NDI-034858; TAK-279

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

JAK

Type

Reference compound

Related Pathways

Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/zasocitinib.html

Purity

99.24

Solubility

DMSO : 50 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

CO[C@H](CC1)[C@@H]1NC(C2=C3N(N=C2)C(NC)=CC(NC4=CC=CN(C5=CC=CC=N5)C4=O)=N3)=O

Molecular Formula

C23H24N8O3

Molecular Weight

460.49

Precautions

H302, H315, H319

References & Citations

[1]Masse, Craig E, et al. Pyrazolopyrimidines as TYK2 inhibitors and their preparation: World Intellectual Property Organization, WO2019023468. 2019-01-31.|[2]Leit S, Greenwood J, Carriero S, et al. Discovery of a Potent and Selective Tyrosine Kinase 2 Inhibitor: TAK-279. J Med Chem. 2023;66 (15) :10473-10496.