(R) -Terazosin

(R) -Terazosin is an active R-enantiomer of Terazosin. (R) -Terazosin is a potent α1-adrenoceptor antagonist with Ki values of 6.51 nM, 1.01 nM and 1.97 nM for α1a, α1b and α1d-adrenoceptor, respectively[1].

Product Specifications

CAS Number

[109351-34-0]

UNSPSC

12352005

Hazard Statement

H315-H319-H320

Target

Adrenergic Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Field of Research

Endocrinology

Assay Protocol

https://www.medchemexpress.com/r-terazosin.html

Purity

99.76

Solubility

DMSO : 25 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(N1CCN(C2=NC(N)=C3C=C(OC)C(OC)=CC3=N2)CC1)[C@@H]4OCCC4

Molecular Formula

C19H25N5O4

Molecular Weight

387.43

Precautions

P264-P280-P302+P352-P305+P351+P338-P362

References & Citations

[1]Hancock AA, et al. Actions of terazosin and its enantiomers at subtypes of alpha 1- and alpha 2-adrenoceptors in vitro. J Recept Signal Transduct Res. 1995 Sep-Dec;15 (7-8) :863-85.