OT-R antagonist 2

OT-R antagonist 2 is a nonpeptide low molecular weight OT-R antagonist. OT-R antagonist 2 inhibitis IP3-Synthesis, rat OT-R (IC50 = 0.33 μM) . IC50 value: 0.33μM Target: oxytocin receptor

Product Specifications

CAS Number

[364071-16-9]

Product Name Alternative

Oxytocin receptor antagonist 2

UNSPSC

12352005

Target

Oxytocin Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Field of Research

Endocrinology

Assay Protocol

https://www.medchemexpress.com/OT-R-antagonist-2.html

Purity

99.86

Solubility

10 mM in DMSO

Smiles

O=C([C@H](C/1)N(C(C2=CC=C(C3=CC=CC=C3C)C=C2)=O)CC1=N\OC)NC[C@@H](O)C4=CC=CC=C4

Molecular Formula

C28H29N3O4

Molecular Weight

471.55

References & Citations

[1]Cirillo R, et al. Pharmacology of (2S,4Z) -N-[ (2S) -2-hydroxy-2-phenylethyl]-4- (methoxyimino) -1-[ (2'-methyl[1,1'-biphenyl]-4-yl) carbonyl]-2-pyrrolidinecarboxamide, a new potent and selective nonpeptide antagonist of the oxytocin receptor. J Pharmacol Exp Ther. 2003 Jul;306 (1) :253-61.|[2]William Nadler, et al. Method for preparing pyrrolidine oximes. WO/2005082848/A2.|[3]Serge Halazy, et al. Pharmaceutically active pyrrolidine derivatives as bax inhibitors.WO/2001074769/A1.|[4]Serge Halazy, et al. Pharmaceutically active pyrrolidine derivatives as bax inhibitors. WO/2001072705/A1.