S-5751
S-5751 is an orally active prostaglandin DP receptor antagonist. S-5751 inhibits cAMP generation in platelet-rich plasma induced by PGD2 with IC50 0.12 μM. S-5751 has anti-inflammatory activity. S-5751 can be used in asthma research[1].
Product Specifications
CAS Number
[209268-36-0]
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
Prostaglandin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/s-5751.html
Solubility
10 mM in DMSO
Smiles
O=C(C(C1=C2)=CSC1=CC=C2O)N[C@H]3[C@@]4([H])C(C)([C@](C[C@@H]3C/C=C\CCCC(O)=O)([H])C4)C
Molecular Formula
C25H31NO4S
Molecular Weight
441.58
Precautions
P261-P280-P302+P352
References & Citations
[1]Shichijo M, et al. A prostaglandin D2 receptor antagonist modifies experimental asthma in sheep. Clin Exp Allergy. 2009 Sep;39 (9) :1404-14.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-19755/S-5751-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-19755/
Scientific Category
Reference compound1
Clinical Information
Phase 2
Available Sizes
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