S-5751

S-5751 is an orally active prostaglandin DP receptor antagonist. S-5751 inhibits cAMP generation in platelet-rich plasma induced by PGD2 with IC50 0.12 μM. S-5751 has anti-inflammatory activity. S-5751 can be used in asthma research[1].

Product Specifications

CAS Number

[209268-36-0]

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Prostaglandin Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/s-5751.html

Solubility

10 mM in DMSO

Smiles

O=C(C(C1=C2)=CSC1=CC=C2O)N[C@H]3[C@@]4([H])C(C)([C@](C[C@@H]3C/C=C\CCCC(O)=O)([H])C4)C

Molecular Formula

C25H31NO4S

Molecular Weight

441.58

Precautions

P261-P280-P302+P352

References & Citations

[1]Shichijo M, et al. A prostaglandin D2 receptor antagonist modifies experimental asthma in sheep. Clin Exp Allergy. 2009 Sep;39 (9) :1404-14.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

Phase 2

Available Sizes

Curated Selection

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