Levofloxacin N-oxide

Levofloxacin N-oxide is a minor metabolite of Levofloxacin (HY-B0330) . Levofloxacin N-oxide does not exhibit significantly genotoxic risks. Levofloxacin is an orally active antibiotic and is active against both Gram-positive and Gram-negative bacteria[1][2].

Product Specifications

CAS Number

[117678-38-3]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Drug Metabolite

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/levofloxacin-n-oxide.html

Purity

98.28

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C(C(C1=O)=CN2[C@@H](C)COC3=C(N4CC[N+](C)([O-])CC4)C(F)=CC1=C23)O

Molecular Formula

C18H20FN3O5

Molecular Weight

377.37

Precautions

H302, H315, H319, H335

References & Citations

[1]Zhu Q, et al. In silico and in vitro genotoxicity evaluation of levofloxacin n-oxide, an impurity in levofloxacin. Toxicol Mech Methods. 2012 Apr;22 (3) :225-30.|[2]Nightingale CH, et al. Pharmacodynamics and pharmacokinetics of levofloxacin. Chemotherapy. 2000;46 Suppl 1:6-14.