TFCP2L1-IN-1
TFCP2L1-IN-1 is a specific small molecule targeting TFCP2L1’s active domain with anti-cancer activity. TFCP2L1-IN-1 synergizes with Sorafenib to induce Apoptosis and reduces cell proliferation, invasion, metastasis, clonal formation and sphere-forming capacity in hepatocellular carcinoma cells[1].
Product Specifications
CAS Number
364621-46-5
UNSPSC
12352211
Target
Apoptosis; Connective Peptide
Type
Reference compound
Related Pathways
Apoptosis; Stem Cell/Wnt
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/tfcp2l1-in-1.html
Concentration
10mM
Purity
99.66
Solubility
DMSO : 175 mg/mL (ultrasonic)
Smiles
BrC1=CC=CC(C(NC(NC2=CC=CC=C2C)=S)=O)=C1
Molecular Formula
C15H13BrN2OS
Molecular Weight
349.25
References & Citations
[1]Qiu D, et al. TFCP2L1 drives stemness and enhances their resistance to Sorafenib treatment by modulating the NANOG/STAT3 pathway in hepatocellular carcinoma. Oncogenesis. 2024 Sep 12;13 (1) :33.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
TFCP2
Available Sizes
Frequently Asked Questions
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