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TFCP2L1-IN-1

TFCP2L1-IN-1 is a specific small molecule targeting TFCP2L1’s active domain with anti-cancer activity. TFCP2L1-IN-1 synergizes with Sorafenib to induce Apoptosis and reduces cell proliferation, invasion, metastasis, clonal formation and sphere-forming capacity in hepatocellular carcinoma cells[1].

Product Specifications

CAS Number

364621-46-5

UNSPSC

12352211

Target

Apoptosis; Connective Peptide

Type

Reference compound

Related Pathways

Apoptosis; Stem Cell/Wnt

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/tfcp2l1-in-1.html

Concentration

10mM

Purity

99.66

Solubility

DMSO : 175 mg/mL (ultrasonic)

Smiles

BrC1=CC=CC(C(NC(NC2=CC=CC=C2C)=S)=O)=C1

Molecular Formula

C15H13BrN2OS

Molecular Weight

349.25

References & Citations

[1]Qiu D, et al. TFCP2L1 drives stemness and enhances their resistance to Sorafenib treatment by modulating the NANOG/STAT3 pathway in hepatocellular carcinoma. Oncogenesis. 2024 Sep 12;13 (1) :33.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

TFCP2

Available Sizes

Frequently Asked Questions

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