Tiratricol

Tiratricol is an orally available thyroid hormone analog that inhibits pituitary thyroid-stimulating hormone secretion. Tiratricol is an intracellular toxin neutralizer that inhibits LPS and lipid A cytotoxicity with IC50s of 20 μM and 32 μM, respectively. Tiratricol reduces TNF production in lipopolysaccharide-stimulated macrophages. Tiratricol also has antiviral activity and is an inhibitor of yellow fever virus (Flavivirus) . It can bind to the RdRp domain of the viral NS5 protein to hinder YFV replication.[2].

Product Specifications

CAS Number

[51-24-1]

Product Name Alternative

3,3',5-Triiodothyroacetic acid

UNSPSC

12352005

Hazard Statement

H302+H312+H332

Target

Flavivirus; Thyroid Hormone Receptor; TNF Receptor

Type

Reference compound

Related Pathways

Anti-infection; Apoptosis; Vitamin D Related/Nuclear Receptor

Field of Research

Endocrinology

Assay Protocol

https://www.medchemexpress.com/Tiratricol.html

Purity

99.60

Solubility

DMSO : ≥ 42 mg/mL

Smiles

O=C(O)CC1=CC(I)=C(OC2=CC=C(O)C(I)=C2)C(I)=C1

Molecular Formula

C14H9I3O4

Molecular Weight

621.93

Precautions

H302+H312+H332

References & Citations

[1]Ren H, et al. Tiratricol inhibits yellow fever virus replication through targeting viral RNA-dependent RNA polymerase of NS5. Antiviral Res. 2023 Nov;219:105737.|[2]Cascales L, et al. Tiratricol neutralizes bacterial endotoxins and reduces lipopolysaccharide-induced TNF-alpha production in the cell. Chem Biol Drug Des. 2008 Oct;72 (4) :320-8.