RA375
RA375 is a RPN13 (26S proteasome regulatory subunit) inhibitor. RA375 activates UPR signaling, ROS production and apoptosis. RA375 exhibits ten-fold greater activity against cancer lines than RA190, reflecting its nitro ring substituents and the addition of a chloroacetamide warhead[1].
Product Specifications
CAS Number
2649154-57-2
UNSPSC
12352005
Target
Apoptosis; Proteasome; Reactive Oxygen Species (ROS)
Type
Peptides
Related Pathways
Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ra375.html
Purity
99.87
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C([C@@H](NC(CCl)=O)CC1=CC=CC=C1)N(C/C(C/2=O)=C\C3=CC=C([N+]([O-])=O)C=C3)CC2=C/C4=CC=C([N+]([O-])=O)C=C4
Molecular Formula
C30H25ClN4O7
Molecular Weight
589.00
References & Citations
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Peptides
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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