JMV7048
Product Specifications
CAS Number
2871774-88-6
UNSPSC Description
JMV7048 is an effective PROTAC degrader targeting PXR (Pregnane X Receptor) with a DC50 of 379 nM. JMV7048 induces the polyubiquitination and degradation of PXR protein by recruiting E3 CRBN ubiquitin ligase and the 26S proteasome. JMV7048 significantly enhances the sensitivity of colon cancer stem cells to chemotherapy by reducing the expression of PXR protein in these cells, thereby significantly delaying cancer recurrence in vivo. JMV7048 is composed of the PXR agonist JMV6944 (HY-162738), linker (HY-162736), and Thalidomide 5-fluoride (HY-W087383) (Red: JMV6944; Blue: Thalidomide 5-fluoride ligand; Black: linker)[1].
Target Antigen
PROTACs
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/jmv7048.html
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=S(NC1=CC=C(N(CC2=CC=CC=C2)C(CCCCCCCNC(CCCCCN3CCN(C4=CC=C(C(N(C5CCC(NC5=O)=O)C6=O)=O)C6=C4)CC3)=O)=N7)C7=C1)(C8=C(C)C=C(C)C=C8C)=O
Molecular Weight
957.19
References & Citations
[1]Bansard L, et al. A potent agonist-based PROTAC targeting Pregnane X Receptor that delays colon cancer relapse[J]. 2024.
Shipping Conditions
Room Temperature
Clinical Information
No Development Reported
Available Sizes
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