Torsemide-d7

Torsemide-d7 is the deuterium labeled Torsemide. Torsemide (Torasemide) is an orally active loop diuretic. Torsemide has anti-aldosterone and vasodilatory effects. Torsemide also can be used for the research of heart failure, renal disease and hepatic cirrhosis[1][1][3].

Product Specifications

CAS Number

[1189375-06-1]

Product Name Alternative

Torasemide-d7

UNSPSC

12352005

Hazard Statement

H319

Target

Isotope-Labeled Compounds

Type

Isotope-Labeled Compounds

Related Pathways

Others

Field of Research

Metabolic Disease; Cardiovascular Disease

Purity

99.77

Solubility

DMSO : 25mg/mL (ultrasonic)

Smiles

CC1=CC(NC2=CC=NC=C2S(NC(NC([2H])(C([2H])([2H])[2H])C([2H])([2H])[2H])=O)(=O)=O)=CC=C1

Molecular Formula

C16H13D7N4O3S

Molecular Weight

355.46

Precautions

P264-P280-P305+P351+P338

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Ishido, H., et al. Torasemide for the Treatment of Heart Failure. Cardiovascular & Hematological Disorders-Drug Targets. 2008. 8 (2), 127–132.|[3]Goodfriend, T. L., et al. Torsemide inhibits aldosterone secretion in vitro. Life Sciences. 1998. 63 (3), PL45–PL50.|[4]H A Friedel, et al. Torasemide. A review of its pharmacological properties and therapeutic potential. Drugs. 1991 Jan;41 (1) :81-103.