Ophiopogonin D'

Ophiopogonin D' is a steroidal saponin and a SIRT1 activator. Ophiopogonin D' can also regulate the activities of transporters OATP1B1 and OATP1B3. Ophiopogonin D' exhibits certain toxicity to tumor cells. Ophiopogonin D' can be used in tumor research[1][2][3].

Product Specifications

CAS Number

[65604-80-0]

UNSPSC

12352005

Target

OAT; Sirtuin

Type

Natural Products

Related Pathways

Cell Cycle/DNA Damage; Epigenetics; Membrane Transporter/Ion Channel

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ophiopogonin-d-1.html

Purity

99.94

Solubility

Ethanol : 5 mg/mL (ultrasonic)

Smiles

C[C@@]12[C@]3([H])[C@](O[C@]4(CC[C@@H](C)CO4)[C@H]3C)([H])C[C@@]1([H])[C@@]5([H])[C@]([C@@]6(C(C[C@@H](O[C@@]7([H])[C@@H]([C@H]([C@H](O)[C@@H](CO)O7)O[C@@]8([H])[C@@H]([C@H]([C@H](O)CO8)O)O)O[C@@]9([H])[C@@H]([C@@H]([C@@H](O)[C@H](C)O9)O)O)CC6)=CC5)C)([H])CC2

Molecular Formula

C44H70O16

Molecular Weight

855.02

References & Citations

[1]Wang L , et al. Homo-aro-cholestane, furostane and spirostane saponins from the tubers of Ophiopogonjaponicus. Phytochemistry. 2017 Apr;136:125-132.|[2]Wang Y, et al. Specific Turn-On Fluorescent Probe with Aggregation-Induced EmissionCharacteristics for SIRT1 Modulator Screening and Living-Cell Imaging. Anal Chem. 2015;87 (10) :5046-9.|[3]Chen L, et al. Modulation of transporter activity of OATP1B1 and OATP1B3 by the major active components of Radix Ophiopogonis. Xenobiotica. 2019 Oct;49 (10) :1221-1228.