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CB 300919

CB 300919 is a quinazoline-based antitumour agent with high activity in the CH1 human ovarian tumour xenograft. CB 300919 has a continuous exposure (96 h) growth inhibition IC50 value of 2 nM in human CH1 ovarian tumor xenograft[1]. CB 300919 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Product Specifications

CAS Number

289715-28-2

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

NAMPT

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/CB-300919.html

Purity

99.10

Solubility

DMSO : ≥ 100 mg/mL|H2O : < 0.1 mg/mL (ultrasonic)

Smiles

CN1CCN(CC1)CC2=NC3=C(C(N2C)=O)C=C(CN(CC#C)C4=CC=C(C=C4)C(NCC5=CC=CN=C5)=O)C(Cl)=C3

Molecular Formula

C32H34ClN7O2

Molecular Weight

584.11

Precautions

H302, H315, H319, H335

References & Citations

[1]Bavetsias, V. et al. The Design and Synthesis of Water-Soluble Analogues of CB30865, a Quinazolin-4-one-Based Antitumor Agent. Journal of Medicinal Chemistry (2002), 45 (17), 3692-3702.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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