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PVRIG, Mouse (HEK293, Fc-Avi)

PVRIG Protein, a member of the nectin and nectin-like family, is an immune checkpoint molecule with potential for development. PVRIG binds with high affinity to PVRL2 are inhibitory receptors on effector T cells, suppressing cytokine production and cytotoxic activity. PVRIG blocking antibodies significantly increased NK-cell cytotoxicity. PVRIG Protein, Mouse (HEK293, Fc-Avi) is the recombinant mouse-derived PVRIG protein, expressed by HEK293 , with C-Avi, C-hFc labeled tag.

Product Specifications

Product Name Alternative

PVRIG Protein, Mouse (HEK293, Fc-Avi), Mouse, HEK293

UNSPSC

12352202

Type

Recombinant Proteins

Assay Protocol

https://www.medchemexpress.com/cytokines/pvrig-protein-mouse-hek293-fc-avi.html

Molecular Formula

102640920 (Gene_ID) A0A1B0GS01 (S35-D165) (Accession)

Molecular Weight

Approximately 53-63 kDa, based on SDS-PAGE under reducing conditions, due to the glycosylation.

References & Citations

[1]Li J, et al. PVRIG is a novel natural killer cell immune checkpoint receptor in acute myeloid leukemia. Haematologica. 2021 Dec 1;106 (12) :3115-3124.|[2]Whelan S, et al. PVRIG and PVRL2 Are Induced in Cancer and Inhibit CD8+ T-cell Function. Cancer Immunol Res. 2019 Feb;7 (2) :257-268.|[3]Li Y, et al. Blockade of checkpoint receptor PVRIG unleashes anti-tumor immunity of NK cells in murine and human solid tumors. J Hematol Oncol. 2021 Jun 26;14 (1) :100.

Shipping Conditions

Room temperature in continental US; may vary elsewhere.

Scientific Category

Recombinant Proteins

Frequently Asked Questions

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