W-84 (dibromide)

W-84 (dibromide) is a potent allosteric modulator of M2-cholinoceptors, which retards [3H]N-methylscopolamine dissociation. W-84 dibromide can stabilize cholinergic antagonist-receptor complexes. W-84 (dibromide) is a non-competitive muscarinic acetylcholine receptors antagonist with allosteric effects. W-84 (dibromide) protects over additively against an organophosphate-intoxication when applied in combination with atropine[1][2][3].

Product Specifications

CAS Number

[21093-51-6]

Product Name Alternative

HDMPPA

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

MAChR

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/w-84-dibromide.html

Purity

98.04

Solubility

DMSO : 6.25 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : 3.03 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

C[N+](C)(CCCN(C(C1=C2C=CC=C1)=O)C2=O)CCCCCC[N+](C)(CCCN(C(C3=C4C=CC=C3)=O)C4=O)C.[Br-].[Br-]

Molecular Formula

C32H44Br2N4O4

Molecular Weight

708.52

Precautions

H315, H319, H335

References & Citations

[1]Jepsen K, et al. Allosteric stabilization of 3H-N-methylscopolamine binding in guinea-pig myocardium by an antidote against organophosphate intoxication. Pharmacol Toxicol. 1988;63 (3) :163-168.|[2]Mohr K, et al. Equipotent allosteric effect of W84 on [3H]NMS-binding to cardiac muscarinic receptors from guinea-pig, rat, and pig. Pharmacol Toxicol. 1992;70 (3) :198-200.|[3]Grossmüller M, et al. Allosteric site in M2 acetylcholine receptors: evidence for a major conformational change upon binding of an orthosteric agonist instead of an antagonist. Naunyn Schmiedebergs Arch Pharmacol. 2006;372 (4) :267-276.