A-65282

A-65282 is an antibacterial agent. A-65282 inhibits P4 DNA unknotting with an IC50 value of 8 µg/mL. A 65281 induces DNA breakage mediated by calf thymus topoisomerase II[1].

Product Specifications

CAS Number

135906-72-8

UNSPSC

12352005

Target

Bacterial; DNA/RNA Synthesis

Type

Reference compound

Related Pathways

Anti-infection; Cell Cycle/DNA Damage

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/a-65282.html

Smiles

O=C1NSC(N(C2CC2)C3=C4C=C(F)C(N5CC(N)CC5)=C3F)=C1C4=O

Molecular Formula

C17H16F2N4O2S

Molecular Weight

378.40

References & Citations

[1]Kohlbrenner WE, et al. Induction of calf thymus topoisomerase II-mediated DNA breakage by the antibacterial isothiazoloquinolones A-65281 and A-65282. Antimicrob Agents Chemother. 1992 Jan;36 (1) :81-6.|[2]Kohlbrenner WE, et al. Induction of calf thymus topoisomerase II-mediated DNA breakage by the antibacterial isothiazoloquinolones A-65281 and A-65282. Antimicrob Agents Chemother. 1992 Jan;36 (1) :81-6.