AKR1C3-IN-4

AKR1C3-IN-4 is a potent and selective aldo-keto reductase 1C3 (AKR1C3) inhibitor with an IC50 of 0.56 μM. AKR1C3-IN-4 has the potential for castrate resistant prostate cancer (CRPC) research[1].

Product Specifications

CAS Number

[1284180-11-5]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

17β-HSD

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/akr1c3-in-4.html

Concentration

10mM

Purity

99.77

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(O)C1=CC=CC(NC2=CC=C(C(F)(F)F)C=C2)=C1

Molecular Formula

C14H10F3NO2

Molecular Weight

281.23

Precautions

H302, H315, H319, H335

References & Citations

[1]Adegoke O Adeniji, et al. Development of potent and selective inhibitors of aldo-keto reductase 1C3 (type 5 17β-hydroxysteroid dehydrogenase) based on N-phenyl-aminobenzoates and their structure-activity relationships. J Med Chem. 2012 Mar 8;55 (5) :2311-23.