Endothelin-1/EDN1, Rat (His-KSI)

Endothelin-1/Edn1 protein is an endothelium-derived vasoconstrictor peptide that plays a crucial role in vascular regulation.As a possible ligand of the G protein-coupled receptors EDNRA and EDNRB, it initiates a signaling cascade involving PTK2B, BCAR1, BCAR3 and the GTPases RAP1 and RHOA in glomerular mesangial cells, helping to regulate vascular tone.Endothelin-1/EDN1 Protein, Rat (His-KSI) is the recombinant rat-derived Endothelin-1/EDN1 protein, expressed by E.coli , with N-6*His, N-KSI labeled tag.