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STX-0119

STX-0119 is a selective, orally active STAT3 dimerization inhibitor. STX-0119 inhibits STAT3 transcription with an IC50 of 74 μM[1].

Product Specifications

CAS Number

851095-32-4

UNSPSC

12352005

Target

STAT

Type

Reference compound

Related Pathways

JAK/STAT Signaling; Stem Cell/Wnt

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/stx-0119.html

Concentration

10mM

Purity

98.40

Solubility

DMSO : 13.33 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(C1=CC(C2=CC=CC=C2)=NC3=C1C=CC=C3)NC4=NN=C(C5=CC=CO5)O4

Molecular Formula

C22H14N4O3

Molecular Weight

382.37

References & Citations

[1]Matsuno K, et al. Identification of a New Series of STAT3 Inhibitors by Virtual Screening. ACS Med Chem Lett. 2010 Jul 13;1 (8) :371-5.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, protect from light)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

STAT3

Available Sizes

Frequently Asked Questions

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