RMC-4627
RMC-4627 is a selective mTORC1 inhibitor that activates 4EBP1 and inhibits tumor growth.
Product Specifications
CAS Number
2250059-52-8
UNSPSC
12352005
Target
MTOR
Type
Reference compound
Related Pathways
PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/rmc-4627.html
Purity
99.20
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
NC1=C2C(C3=CC4=CC(O)=CC=C4N3)=NN(C2=NC=N1)CCCCNC(CCOCCOCCOCCOCCOCCOCCOCCOCCN5C=C(N=N5)CCCCO[C@H]6[C@@H](C[C@@H](CC6)C[C@H]([C@@]7([H])OC([C@@]8([H])N(CCCC8)C(C([C@@]9(O[C@](CC[C@H]9C)([H])C[C@@H](/C(C)=C/C=C/C=C/[C@H](C[C@H](C([C@@H]([C@@H](/C(C)=C/[C@H](C(C7)=O)C)O)OC)=O)C)C)OC)O)=O)=O)=O)C)OC)=O
Molecular Formula
C93H141N11O23
Molecular Weight
1781.17
References & Citations
[1]Lee BJ, et al. Selective inhibitors of mTORC1 activate 4EBP1 and suppress tumor growth. Nat Chem Biol. 2021 Oct;17 (10) :1065-1074.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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