Phospho-Btk (Tyr223) Rabbit APC Conjugate

<strong>Phospho-Btk (Tyr223) Rabbit APC Conjugate </strong>_x000D_ <strong>Catalog number:</strong> B2018636_x000D_ <strong>Lot number:</strong> Batch Dependent_x000D_ <strong>Expiration Date:</strong> Batch dependent_x000D_ <strong>Amount:</strong> 10 ug_x000D_ <strong>Molecular Weight or Concentration:</strong> N/A_x000D_ <strong>Supplied as:</strong> Solution_x000D_ <strong>Applications:</strong> a molecular tool for various biochemical applications_x000D_ <strong>Storage:</strong> 2-8°C_x000D_ <strong>Keywords:</strong> Bruton tyrosine kinase, Tyrosine-protein kinase BTK, Agammaglobulinemia tyrosine kinase, ATK, AGMX1, B-cell progenitor kinase, BPK_x000D_ <strong>Grade:</strong> Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity &gt;18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ <strong>References:</strong>_x000D_ 1: Wu H, Wang W, Liu F, Weisberg EL, Tian B, Chen Y, Li B, Wang A, Wang B, Zhao Z, McMillin DW, Hu C, Li H, Wang J, Liang Y, Buhrlage SJ, Liang J, Liu J, Yang G, Brown JR, Treon SP, Mitsiades CS, Griffin JD, Liu Q, Gray NS. Discovery of a potent, covalent BTK inhibitor for B-cell lymphoma ACS Chem Biol. 2014 May 16;9(5):1086-91._x000D_ 2: Novero A, Ravella PM, Chen Y, Dous G, Liu D. Ibrutinib for B cell malignancies Exp Hematol Oncol. 2014 Jan 28;3(1):4._x000D_ 3: Kurosaki T, Kurosaki M. Transphosphorylation of Bruton's tyrosine kinase on tyrosine 551 is critical for B cell antigen receptor function J Biol Chem. 1997 Jun 20;272(25):15595-8._x000D_ 4: Chen H, Song P, Diao Y, Hao Y, Dou D, Wang W, Fang X, Wang Y, Zhao Z, Ding J, Li H, Xie H, Xu Y. Discovery and biological evaluation of N5-substituted 6,7-dioxo-6,7-dihydropteridine derivatives as potent Bruton's tyrosine kinase inhibitors Medchemcomm. 2018 Mar 13;9(4):697-704._x000D_ 5: Chen LS, Bose P, Cruz ND, Jiang Y, Wu Q, Thompson PA, Feng S, Kroll MH, Qiao W, Huang X, Jain N, Wierda WG, Keating MJ, Gandhi V. A pilot study of lower doses of ibrutinib in patients with chronic lymphocytic leukemia Blood. 2018 Nov 22;132(21):2249-2259._x000D_ 6: Li Z, Wahl MI, Eguinoa A, Stephens LR, Hawkins PT, Witte ON. Phosphatidylinositol 3-kinase-gamma activates Bruton's tyrosine kinase in concert with Src family kinases Proc Natl Acad Sci U S A. 1997 Dec 9;94(25):13820-5._x000D_ 7: Velavalapalli VM, Maddipati VC, Gurská S, Annadurai N, Lišková B, Katari NK, Džubák P, Hajdúch M, Das V, Gundla R. Novel 5-Substituted Oxindole Derivatives as Bruton's Tyrosine Kinase Inhibitors: Design, Synthesis, Docking, Molecular Dynamics Simulation, and Biological Evaluation ACS Omega. 2024 Feb 7;9(7):8067-8081._x000D_ 8: Suzuki-Inoue K, Wilde JI, Andrews RK, Auger JM, Siraganian RP, Sekiya F, Rhee SG, Watson SP. Glycoproteins VI and Ib-IX-V stimulate tyrosine phosphorylation of tyrosine kinase Syk and phospholipase Cgamma2 at distinct sites Biochem J. 2004 Mar 15;378(Pt 3):1023-9._x000D_ 9: Bittner ZA, Liu X, Mateo Tortola M, Tapia-Abellán A, Shankar S, Andreeva L, Mangan M, Spalinger M, Kalbacher H, Düwell P, Lovotti M, Bosch K, Dickhöfer S, Marcu A, Stevanović S, Herster F, Cardona Gloria Y, Chang TH, Bork F, Greve CL, Löffler MW, Wolz OO, Schilling NA, Kümmerle-Deschner JB, Wagner S, Delor A, Grimbacher B, Hantschel O, Scharl M, Wu H, Latz E, Weber ANR. BTK operates a phospho-tyrosine switch to regulate NLRP3 inflammasome activity J Exp Med. 2021 Nov 1;218(11):e20201656._x000D_ <a href="https://pubmed.ncbi.nlm.nih.gov/35212958">10: Shankar S, Bittner ZA, Weber ANR. NLRP3 Phospho-residue Mapping by Phospho Dot Blots Methods Mol Biol. 2022;2459:93-103. </a>_x000D_ _x000D_ <strong>Products Related to Phospho-Btk (Tyr223) Rabbit APC Conjugate can be found at</strong> <a href="https://moleculardepot.com/product-category/Proteins/"> Proteins</a>