Glyphosate

Glyphosate, a non-selective systemic biocide with broad-spectrum activity, is an herbicidal derivative of the amino acid glycine. Glyphosate inhibits the enzymatic activity of the 5-endopyruvylshikimate 3-phosphate synthase (EPSPS) in the shikimic acid pathway, preventing the synthesis of the aromatic amino acids tyrosine, phenylalanine, and tryptophan. Glyphosate induces oxidative stress, neuroinflammation, and mitochondrial dysfunction, processes that lead to neuronal death by autophagia, necrosis, or apoptosis, as well as the appearance of behavioral and motor disorders[1][2][3].

Product Specifications

CAS Number

[1071-83-6]

UNSPSC

12352211

Hazard Statement

H312, H318, H411

Target

Apoptosis; Autophagy; Necroptosis

Type

Reference compound

Related Pathways

Apoptosis; Autophagy

Applications

Cancer-programmed cell death

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/glyphosate.html

Purity

98.00

Solubility

H2O : 13.33 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(O)CNCP(O)(O)=O

Molecular Formula

C3H8NO5P

Molecular Weight

169.07

Precautions

H312, H318, H411

References & Citations

[1]Greim H, et al. Evaluation of carcinogenic potential of the herbicide glyphosate, drawing on tumor incidence data from fourteen chronic/carcinogenicity rodent studies. Crit Rev Toxicol. 2015;45 (3) :185-208.|[2]Zhang JW, et al The toxic effects and possible mechanisms of glyphosate on mouse oocytes. Chemosphere. 2019 Dec;237:124435.|[3]Carmen Costas-Ferreira, et al. Toxic Effects of Glyphosate on the Nervous System: A Systematic Review. Int J Mol Sci. 2022 Apr 21;23 (9) :4605.