Glyphosate
Product Specifications
UNSPSC Description
Glyphosate, a non-selective systemic biocide with broad-spectrum activity, is an herbicidal derivative of the amino acid glycine. Glyphosate inhibits the enzymatic activity of the 5-endopyruvylshikimate 3-phosphate synthase (EPSPS) in the shikimic acid pathway, preventing the synthesis of the aromatic amino acids tyrosine, phenylalanine, and tryptophan. Glyphosate induces oxidative stress, neuroinflammation, and mitochondrial dysfunction, processes that lead to neuronal death by autophagia, necrosis, or apoptosis, as well as the appearance of behavioral and motor disorders[1][2][3].
Target Antigen
Apoptosis; Autophagy; Necroptosis
Type
Reference compound
Related Pathways
Apoptosis;Autophagy
Applications
Cancer-programmed cell death
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/glyphosate.html
Purity
98.0
Solubility
H2O : 13.89 mg/mL (ultrasonic)
Smiles
O=C(O)CNCP(O)(O)=O
Molecular Weight
169.07
References & Citations
[1]Greim H, et al. Evaluation of carcinogenic potential of the herbicide glyphosate, drawing on tumor incidence data from fourteen chronic/carcinogenicity rodent studies. Crit Rev Toxicol. 2015;45(3):185-208.|[2]Zhang JW, et al The toxic effects and possible mechanisms of glyphosate on mouse oocytes. Chemosphere. 2019 Dec;237:124435.|[3]Carmen Costas-Ferreira, et al. Toxic Effects of Glyphosate on the Nervous System: A Systematic Review. Int J Mol Sci. 2022 Apr 21;23(9):4605.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-B0863/Glyphosate-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-B0863/Glyphosate-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
1071-83-6
Available Sizes
Curated Selection
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