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Trastuzumab rezetecan

Trastuzumab rezetecan (SHR-A1811) is a HER2-targeting antibody-drug conjugate (ADC) . Trastuzumab rezetecan is composed of a humanized anti-HER2 antibody (HY-P9907), a cleavable linker MC-Gly-Gly-Phe-Gly (HY-44246), and a topoisomerase I inhibitor payload Rezetecán (HY-147408) . Trastuzumab rezetecan can be used for research in HER2-positive breast cancer[1].

Product Specifications

CAS Number

[2924909-11-3]

Product Name Alternative

SHR-A1811

UNSPSC

12352203

Target

Antibody-Drug Conjugates (ADCs) ; EGFR

Type

ADC Related

Related Pathways

Antibody-drug Conjugate/ADC Related; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/trastuzumab-rezetecan.html

Purity

98.61

Smiles

[Trastuzumabrezetecan]

References & Citations

[1]Khalil Saleh, et al. Mechanisms of action and resistance to anti-HER2 antibody-drug conjugates in breast cancer. Cancer Drug Resist. 2024 Jun 3:7:22.

Shipping Conditions

Dry Ice

Storage Conditions

-80°C, protect from light

Scientific Category

ADC Related

Clinical Information

Phase 3

Isoform

ErbB2/HER2

Available Sizes

Curated Selection

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