2-Aminoimidazole

2-Aminoimidazole is a potent antibiofilm agent that can be used as an adjuvant to antimicrobial. 2-aminoimidazoles disrupts the ability of bacteria to protect themselves by inhibiting biofilm formation and genetically-encoded antibiotic resistance traits. 2-Aminoimidazole is also a weak noncompetitive inhibitor of human arginase I with a Ki of 3.6 mM[1][2][3].

Product Specifications

CAS Number

[7720-39-0]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Arginase; Bacterial

Type

Natural Products

Related Pathways

Anti-infection; Immunology/Inflammation; Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/2-aminoimidazole.html

Purity

98.06

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

NC1=NC=CN1

Molecular Formula

C3H5N3

Molecular Weight

83.09

Precautions

H302, H315, H319, H335

References & Citations

[1]Thompson RJ, et, al. Identification of BfmR, a response regulator involved in biofilm development, as a target for a 2-Aminoimidazole-based antibiofilm agent. Biochemistry. 2012 Dec 11;51 (49) :9776-8.|[2]Jacobs L, et, al. 2-Aminoimidazoles as potent inhibitors of contaminating brewery biofilms. Biofouling. 2021 Feb 11;1-17.|[3]Ilies M, et, al. 2-aminoimidazole amino acids as inhibitors of the binuclear manganese metalloenzyme human arginase I. J Med Chem. 2010 May 27;53 (10) :4266-76.