Vutiglabridin

Vutiglabridin (HSG4112), a racemic compound, is a potent anti-obesity agent[1]. Vutiglabridin, an optimized structural analog of Glabridin, markedly supersedes Glabridin in weight reduction efficacy and chemical stability[1].

Product Specifications

CAS Number

[1800188-47-9]

Product Name Alternative

HSG4112

UNSPSC

12352005

Target

Bacterial; PPAR; Reactive Oxygen Species (ROS)

Type

Reference compound

Related Pathways

Anti-infection; Cell Cycle/DNA Damage; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; Vitamin D Related/Nuclear Receptor

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/vutiglabridin.html

Purity

99.74

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

OC1=CC(OCC)=CC=C1C2COC3=C4CCC(C)(C)OC4=CC=C3C2

Molecular Formula

C22H26O4

Molecular Weight

354.44

References & Citations

[1]In Yong Bae, et al. Species Differences in Stereoselective Pharmacokinetics of HSG4112, A New Anti-Obesity Agent. Pharmaceutics. 2020 Feb 3;12 (2) :127.|[2]Leo Sungwong Choi, et al. Discovery and preclinical efficacy of HSG4112, a synthetic structural analog of glabridin, for the treatment of obesity. Int J Obes (Lond) . 2021 Jan;45 (1) :130-142.