GPX4 activator 2
GPX4 activator 2 (Compound C3) is an activator of GPX4. GPX4 activator 2 exhibits cardioprotective effects and can inhibit cellular ferroptosis (EC50=7.8 μM) . GPX4 activator 2 can be used in the research of myocardial injury[1].
Product Specifications
CAS Number
950365-31-8
UNSPSC
12352005
Target
Ferroptosis; Glutathione Peroxidase
Type
Reference compound
Related Pathways
Apoptosis; Metabolic Enzyme/Protease
Applications
Neuroscience-Neurodegeneration
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/gpx4-activator-2.html
Purity
99.23
Solubility
DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
CN(CC1)CCN1C2=NN=C(S2)N3C=CC=C3CNC4=CC=C(OC)C=C4OC
Molecular Formula
C20H26N6O2S
Molecular Weight
414.52
References & Citations
[1]Liu X, et al. GPX4 allosteric activators inhibit ferroptosis and exert myocardial protection in doxorubicin-induced myocardial injury mouse model. Eur J Med Chem. 2024 Jul 30;277:116721.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
NB001812010 10 PCS
PVDF Transfer Membrane (0.45 μm), 9x7 cm, 10 pcs
Sign In for Pricing
View Details MBS9338584-01 48 Well
Human Serine/threonine-protein kinase Nek11, NEK11 ELISA Kit
Sign In for Pricing
View Details MBS9338584-02 96 Well
Human Serine/threonine-protein kinase Nek11, NEK11 ELISA Kit
Sign In for Pricing
View Details MBS9338584-03 5x 96 Well
Human Serine/threonine-protein kinase Nek11, NEK11 ELISA Kit
Sign In for Pricing
View Details MBS9338584-04 10x 96 Well
Human Serine/threonine-protein kinase Nek11, NEK11 ELISA Kit
Sign In for Pricing
View Details 