Renzapride (hydrochloride)
Renzapride hydrochloride is a benzamide that inhibits irritable bowel syndrome and has antagonistic activity at 5-HT (3) receptors and agonistic activity at 5-HT (4) receptors. Renzapride hydrochloride also exhibits antagonistic activity at 5-HT (2B) receptors and has a certain affinity for 5-HT (2A) and 5-HT (2C) receptors[1].
Product Specifications
CAS Number
[109872-41-5]
UNSPSC
12352005
Target
5-HT Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/renzapride-hydrochloride.html
Smiles
ClC1=C(N)C=C(OC)C(C(N[C@H]2CCN3CCC[C@@H]2C3)=O)=C1.Cl
Molecular Formula
C16H23Cl2N3O2
Molecular Weight
360.28
References & Citations
[1]Pharmacology and metabolism of renzapride : a novel therapeutic agent for the potential treatment of irritable bowel syndrome
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 3
Isoform
5-HT2 Receptor
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PI3K p110, gamma (1 phosphatidylinositol 3 Kinase, 5-bisphosphate 3-Kinase 110 a Catalytic Subunit gamma, 5-bisphosphate 3-Kinase Catalytic Subunit gamma Isoform, p110 gamma, p110gamma, p120 PI3K, p120-PI3K, Phosphatidylinositol 4 5 bisphosphate 3 Kinase 110 a Catalytic Subunit gamma, Phosphatidylinositol 4 5 bisphosphate 3 Kinase Catalytic Subunit gamma, Phosphatidylinositol 4 5 bisphosphate 3 Kinase Catalytic Subunit gamma Isoform, Phosphatidylinositol-4, Phosphoinositide 3 Kinase Catalytic gamma Polypeptide) discontinued
PI3K p110, gamma (1 phosphatidylinositol 3 Kinase, 5-bisphosphate 3-Kinase 110 a Catalytic Subunit gamma, 5-bisphosphate 3-Kinase Catalytic Subunit gamma Isoform, p110 gamma, p110gamma, p120 PI3K, p120-PI3K, Phosphatidylinositol 4 5 bisphosphate 3 Kinase 110 a Catalytic Subunit gamma, Phosphatidylinositol 4 5 bisphosphate 3 Kinase Catalytic Subunit gamma, Phosphatidylinositol 4 5 bisphosphate 3 Kinase Catalytic Subunit gamma Isoform, Phosphatidylinositol-4, Phosphoinositide 3 Kinase Catalytic gamma Polypeptide) discontinued
