ZLD10A
Product Specifications
UNSPSC Description
ZLD10A is a highly potent and selective EZH2 inhibitor with the activity of inhibiting H3K27 methylation. ZLD10A can inhibit wild-type and mutant EZH2 with nanomolar potency and has more than 1000-fold selectivity for the other 10 histone methyltransferases. ZLD10A inhibited cell proliferation of DLBCL cell lines in a concentration- and time-dependent manner, showing a potential antiproliferative effect. ZLD10A can be used in the study of EZH2 mutant lymphomas[1].
Target Antigen
Histone Methyltransferase
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
cancer
Assay Protocol
https://www.medchemexpress.com/zld10a.html
Smiles
O=C(C1=CC(C2=CC=C(CN3CCOCC3)C=C2)=CC(N(C4CCOCC4)CC)=C1C)NCC5=C(CCCC6)C6=C(C)NC5=O
Molecular Weight
612.80
References & Citations
[1]Selective inhibition of EZH2 by ZLD10A blocks H3K27 methylation and kills mutant lymphoma cells proliferation
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-117540/ZLD10A-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-117540/
Clinical Information
No Development Reported
CAS Number
1782064-91-8
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