ZLD10A
ZLD10A is a highly potent and selective EZH2 inhibitor with the activity of inhibiting H3K27 methylation. ZLD10A can inhibit wild-type and mutant EZH2 with nanomolar potency and has more than 1000-fold selectivity for the other 10 histone methyltransferases. ZLD10A inhibited cell proliferation of DLBCL cell lines in a concentration- and time-dependent manner, showing a potential antiproliferative effect. ZLD10A can be used in the study of EZH2 mutant lymphomas[1].
Product Specifications
CAS Number
[1782064-91-8]
UNSPSC
12352005
Target
Histone Methyltransferase
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/zld10a.html
Smiles
O=C(C1=CC(C2=CC=C(CN3CCOCC3)C=C2)=CC(N(C4CCOCC4)CC)=C1C)NCC5=C(CCCC6)C6=C(C)NC5=O
Molecular Formula
C37H48N4O4
Molecular Weight
612.80
References & Citations
[1]Selective inhibition of EZH2 by ZLD10A blocks H3K27 methylation and kills mutant lymphoma cells proliferation
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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