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BAY-5516

BAY-5516 is a inverse-agonist o PPARG, with the IC50 value of 6.1±3.6 nM that has anti-tumor effect[1].

Product Specifications

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

PPAR

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/bay-5516.html

Purity

98.17

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(C1=CC(C(NCC2=CC=C(C=C2)F)=O)=C(C=C1Cl)F)NC3=CC=C(C=C3C)OC(F)F

Molecular Formula

C23H17ClF4N2O3

Molecular Weight

480.84

Precautions

H302, H315, H319, H335

References & Citations

[1]Douglas L Orsi, et al. Discovery and characterization of orally bioavailable 4-chloro-6-fluoroisophthalamides as covalent PPARG inverse-agonists. Bioorg Med Chem. 2023 Jan 15:78:117130.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-160160/BAY-5516-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-160160/BAY-5516-SDS-MedChemExpress.pdf

Scientific Category

Reference compound1

Clinical Information

No Development Reported

CAS Number

[2891706-79-7]

Available Sizes

Curated Selection

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