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Ampicillin (sodium)

Ampicillin sodium (D- (-) -α-Aminobenzylpenicillin sodium salt) is a broad-spectrum beta-lactam antibiotic against a variety of gram-positive and gram-negative bacteria[1].

Product Specifications

CAS Number

[69-52-3]

Product Name Alternative

D- (-) -α-Aminobenzylpenicillin (sodium salt)

UNSPSC

12352005

Hazard Statement

H317, H334

Target

Antibiotic; Bacterial

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/Ampicillin-sodium.html

Purity

98.0

Solubility

H2O : ≥ 200 mg/mL

Smiles

O=C([C@@H]1N(C2=O)[C@]([C@@H]2NC([C@@H](C3=CC=CC=C3)N)=O)([H])SC1(C)C)O[Na]

Molecular Formula

C16H18N3NaO4S

Molecular Weight

371.38

Precautions

H317, H334

References & Citations

[1]Chopra SL, et al. Effect of Ampicillin on E. Coli of Swine Origin. Can J Comp Med Vet Sci. 1963 Sep;27 (9) :223-7.|[2]Lund B, et al. Ampicillin in portal and peripheral blood and bile after oral administration of ampicillin andpivampicillin. Eur J Clin Pharmacol. 1974;7 (2) :133-5.|[3]Lee KE, et al. The neuroprotective mechanism of ampicillin in a mouse model of transient forebrain ischemia. Korean J Physiol Pharmacol. 2016 Mar;20 (2) :185-92.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

Launched

Isoform

β-lactam

Citation 01

ACS Infect Dis. 2024 Aug 9;10 (8) :2961-2977.|ACS Omega. 2023 Mar 6;8 (10) :9652-9661.|Am J Chin Med. 2024 Aug 21:1-28.|Cancer Cell. 2025 Sep 25:S1535-6108 (25) 00394-0.|Cell Host Microbe. 2025 Jun 11;33 (6) :915-931.e9.|Cell Rep Med. 2023 Dec 19;4 (12) :101340.|Chin Med. 2025 Oct 3;20 (1) :155.|Emerg Microbes Infect. 2024 Dec;13 (1) :2321981.|Nano Today. 2025 Oct.|Nucleic Acids Res. 2022 Dec 9;50 (22) :12951-12968.|Sci Adv. 2023 Feb 17;9 (7) :eade4770.|ACS Infect Dis. 2023 Dec 8;9 (12) :2523-2537.|Adv Sci (Weinh) . 2025 Apr 28:e2409837.|AMB Express. 2024 Dec 24;14 (1) :141.|Anim Dis. 2021;1 (1) :26.|Antimicrob Agents Chemother. 2025 Aug 6;69 (8) :e0037925.|Aquaculture. 2021, 736248.|Biochem Biophys Res Commun. 2025 Jun 7:776:152161.|Biochem Pharmacol. 2024 Dec;230 (Pt 2) :116593.|Biomed Pharmacother. 2025 Jan:182:117756.|Biomed Res Int. 2018 Jul 2:2018:3579832.|bioRxiv. 2024 May 10.|bioRxiv. 2025 February 13.|bioRxiv. 2025 January 19.|Cancer Immunol Res. 2022 Dec 2;10 (12) :1542-1558.|Cell Metab. 2023 Nov 7;35 (11) :1961-1975.e6.|Cell Metab. 2025 Jan 7;37 (1) :87-103.e10.|Cell Rep Med. 2025 Oct 21;6 (10) :102410.|Chemosphere. 2023 Dec:344:140353.|Curr Res Food Sci. 2025 May 16:10:101084.|Diagn Microbiol Infect Dis. 2025 Nov 4;114 (2) :117181.|Emerg Microbes Infect. 2022 Dec;11 (1) :815-828.|Front Aging Neurosci. 2022 Jul 28;14:858130.|Genome Biol. 2023 Apr 30;24 (1) :98.|Gut Microbes. 2023 Dec;15 (2) :2249143.|Gut Microbes. 2023 Dec;15 (2) :2282790.|Heliyon. 2024 Jun 6;10 (11) :e32429.|Infect Genet Evol. 2025 Sep:133:105780.|iScience. 2023 Mar 11;26 (4) :106378.|iScience. 2023 Oct 7;26 (11) :108158.|iScience. 2025 May 13;28 (7) :112658.|iScience. 2025 May 27;28 (6) :112763.|J Agric Food Chem. 2024 Apr 10.|J Antimicrob Chemother. 2023 Apr 3;78 (4) :983-990.|J Antimicrob Chemother. 2024 Jul 13:dkae229.|J Antimicrob Chemother. 2024 Jul 20:dkae218.|J Cell Physiol. 2022 Mar;237 (3) :1845-1856.|J Nanobiotechnology. 2024 Nov 30;22 (1) :744.|J Neuroinflammation. 2025 Nov 4;22 (1) :259.|J Pharm Anal. 2023 Oct;13 (10) :1153-1167.|Life Metab. 2025 Oct 8.|Life Sci. 2020 Nov 15;261:118473.|Microbiol Spectr. 2022 Feb 23;10 (1) :e0099121.|Microorganisms. 2024 Mar 13;12 (3) :575.|Microorganisms. 2025 Apr 18;13 (4) :938.|Molecules. 2025 Mar 9;30 (6) :1224.|mSystems. 2023 Dec 21;8 (6) :e0102623.|Nat Commun. 2022 Mar 2;13 (1) :1116.|Naunyn Schmiedebergs Arch Pharmacol. 2025 Apr;398 (4) :3681-3695.|Neural Regen Res. 2024 Sep 1;19 (9) :2081-2088.|Nutrients. 2023 Oct 18;15 (20) :4427.|Pharmacol Res. 2024 May 21:205:107229.|Protoplasma. 2025 Nov 6.|Res Sq. 2024 Oct 02.|Res Sq. 2025 Aug 05.|Research Square Preprint. 2020 Jun.|Research Square Preprint. 2021 Feb.|SSRN. 2023 Sep 11.|Vet Microbiol. 2024 May:292:110046.|Vet Res Commun. 2024 Dec;48 (6) :3859-3872.

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