Revaprazan (hydrochloride)
Revaprazan hydrochloride is reversible proton pump inhibitor. Revaprazan hydrochloride can inhibit gastric acid secretion and protect gastric mucosa. Revaprazan hydrochloride can inhibit IkappaB-alpha degradation as well as Akt inactivation, resulting in attenuation of H. pylori-induced COX-2 expression. Revaprazan hydrochloride can be used for the researches of infection and inflammmation, such as H. pylori-infected gastric inflammation and gastric ulcer[1][2].
Product Specifications
CAS Number
178307-42-1
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Akt; Bacterial; COX; ERK; NF-κB; Proton Pump
Type
Reference compound
Related Pathways
Anti-infection; Immunology/Inflammation; MAPK/ERK Pathway; Membrane Transporter/Ion Channel; NF-κB; PI3K/Akt/mTOR; Stem Cell/Wnt
Applications
Neuroscience-Neuromodulation
Field of Research
Infection; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/revaprazan-hydrochloride.html
Concentration
10mM
Purity
99.98
Solubility
DMSO : 8.33 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
CC1=C(C)C(N2C(C)C3=C(C=CC=C3)CC2)=NC(NC4=CC=C(F)C=C4)=N1.[H]Cl
Molecular Formula
C22H24ClFN4
Molecular Weight
398.90
Precautions
H302, H315, H319, H335
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
COX-2
Citation 01
BMC Microbiol. 2025 Nov 5;25 (1) :715.|Pharmaceuticals (Basel) . 2022 Sep 25;15 (10) :1186.
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