Betazole (dihydrochloride)

Betazole (Ametazole) dihydrochloride, a pyrazole analogue of histamine, is an orally active H2 receptor agonist. Betazole dihydrochloride induces gastric acid secretion, and causes an immediate and significant increase in common bile duct pressure. Betazole dihydrochloride has been used as a diagnostic agent known as histalog, for investigating gastric acid secretory capacity[1][2][3].

Product Specifications

CAS Number

[138-92-1]

Product Name Alternative

Ametazole (dihydrochloride)

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Histamine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/betazole-dihydrochloride.html

Solubility

10 mM in DMSO

Smiles

NCCC1=NNC=C1.[H]Cl.[H]Cl

Molecular Formula

C5H11Cl2N3

Molecular Weight

184.07

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Maples MD, Effects of betazole hydrochloride and cimetidine on common bile pressure and duodenal myoelectric activity in the dog. Am Surg. 1981;47 (12) :519-521.|[2]Spitz IM, Betazole-induced GIP secretion is not mediated by gastric HCl. Metabolism. 1982;31 (4) :380-382.|[3]CLAYMAN CB, . A simple oral gastric secretory stimulant (betazole hydrochloride) . JAMA. 1961;175:908-909.