AG-636
AG-636 is a potent, reversible, selective and orally active dihydroorotate dehydrogenase (DHODH) inhibitor with an IC50 of 17 nM. AG-636 has strong anticancer effects[1].
Product Specifications
CAS Number
[1623416-31-8]
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
Dihydroorotate Dehydrogenase; DNA/RNA Synthesis
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ag-636.html
Concentration
10mM
Purity
98.25
Solubility
DMSO : 31.25 mg/mL (ultrasonic)
Smiles
O=C(C1=C(N(C)N=N2)C2=CC(C3=CC=C(C4=CC=CC=C4C)C=C3)=C1)O
Molecular Formula
C21H17N3O2
Molecular Weight
343.38
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Gabrielle McDonald, et al. Selective Vulnerability to Pyrimidine Starvation in Hematologic Malignancies Revealed by AG-636, a Novel Clinical-Stage Inhibitor of Dihydroorotate Dehydrogenase. Mol Cancer Ther. 2020 Dec;19 (12) :2502-2515.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 1
Available Sizes
Curated Selection
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