AG-636

AG-636 is a potent, reversible, selective and orally active dihydroorotate dehydrogenase (DHODH) inhibitor with an IC50 of 17 nM. AG-636 has strong anticancer effects[1].

Product Specifications

CAS Number

[1623416-31-8]

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Dihydroorotate Dehydrogenase; DNA/RNA Synthesis

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ag-636.html

Concentration

10mM

Purity

98.25

Solubility

DMSO : 31.25 mg/mL (ultrasonic)

Smiles

O=C(C1=C(N(C)N=N2)C2=CC(C3=CC=C(C4=CC=CC=C4C)C=C3)=C1)O

Molecular Formula

C21H17N3O2

Molecular Weight

343.38

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Gabrielle McDonald, et al. Selective Vulnerability to Pyrimidine Starvation in Hematologic Malignancies Revealed by AG-636, a Novel Clinical-Stage Inhibitor of Dihydroorotate Dehydrogenase. Mol Cancer Ther. 2020 Dec;19 (12) :2502-2515.