Sulfaphenazole

Sulfaphenazole is a selective inhibitor of human cytochrome P450 (CYP) 2C9 enzyme. Sulfaphenazole is a cytoprotective agent against light-induced death of photoreceptors. Sulfaphenazole inhibits light-induced necrosis and mitochondrial stress-initiated apoptosis. Sulfaphenazole is an off patent sulfonamide antibiotic and demonstrates bactericidal activity through enhanced M1 macrophage activity. Sulfaphenazole can significantly reduce infarct size and restore post-ischemic coronary flow following ischemia and reperfusion[1][2][3].

Product Specifications

CAS Number

[526-08-9]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Antibiotic; Apoptosis; Bacterial; Cytochrome P450; Necroptosis

Type

Reference compound

Related Pathways

Anti-infection; Apoptosis; Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Infection; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/Sulfaphenazole.html

Concentration

10mM

Purity

99.85

Solubility

DMSO : ≥ 100 mg/mL

Smiles

O=S(C1=CC=C(N)C=C1)(NC2=CC=NN2C3=CC=CC=C3)=O

Molecular Formula

C15H14N4O2S

Molecular Weight

314.36

Precautions

H302, H315, H319, H335

References & Citations

[1]Qing Chang, et al. Cytochrome P450 2C epoxygenases mediate photochemical stress-induced death of photoreceptors. J Biol Chem. 2014 Mar 21;289 (12) :8337-52.|[2]Shahrzad Elmi, et al. Sulfaphenazole treatment restores endothelium-dependent vasodilation in diabetic mice. Vascul Pharmacol. 2008 Jan;48 (1) :1-8.|[3]Christopher T Turner, et al. Sulfaphenazole reduces thermal and pressure injury severity through rapid restoration of tissue perfusion. Sci Rep. 2022 Jul 23;12 (1) :12622.