St-Ht31

St-Ht31 is a membrane-permeable peptide inhibitor of protein kinase A (PKA) anchoring. st-Ht31 induces robust cholesterol/phospholipid efflux. st-Ht31 completely reverses foam cell formation and restores the metabolic health of macrophage[1][2].

Product Specifications

CAS Number

[188425-80-1]

UNSPSC

12352209

Target

PAK

Type

Peptides

Related Pathways

Cell Cycle/DNA Damage; Cytoskeleton

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/st-ht31.html

Solubility

10 mM in DMSO

Smiles

[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@@H](CC1=CC=C(O)C=C1)C(O)=O)=O)C)=O)=O)C)=O)C)=O)CCCCN)=O)[C@@H](C)C)=O)CCC(N)=O)=O)(NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(CCCCCCCCCCCCCCCCC)=O)CC(O)=O)=O)CC(C)C)=O)[C@H](CC)C)=O)CCC(O)=O)=O)CCC(O)=O)=O)C)=O)C)=O)CO)=O)CCCNC(=N)N)=O)[C@H](CC)C)=O)C(C)C)=O)CC(O)=O)=O)C)=O)C(C)C)=O)[C@H](CC)C)=O)CCC(O)=O

Molecular Formula

C129H217N29O39

Molecular Weight

2798.32

References & Citations

[1]Ma L, et al. Ht31, a protein kinase A anchoring inhibitor, induces robust cholesterol efflux and reverses macrophage foam cell formation through ATP-binding cassette transporter A1. J Biol Chem. 2011 Feb 4;286 (5) :3370-8. |[2]Rahamim Ben-Navi L, et al. A-Kinase Anchoring Protein 4 (AKAP4) is an ERK1/2 substrate and a switch molecule between cAMP/PKA and PKC/ERK1/2 in human spermatozoa. Sci Rep. 2016 Nov 30;6:37922.