Enprofylline
Enprofylline acts as a selective and competitive A2B receptor antagonist with the Ki of 7 μM. Enprofylline also acts as a phosphodiesterase inhibitor. Enprofylline can be used for the research of asthma, chronic obstructive pulmonary disease[1][2][3].
Product Specifications
CAS Number
41078-02-8
UNSPSC
12352005
Hazard Statement
H302, H312, H332
Target
Adenosine Receptor; Phosphodiesterase (PDE)
Type
Reference compound
Related Pathways
GPCR/G Protein; Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/enprofylline.html
Purity
98.71
Solubility
DMSO : 62.5 mg/mL (ultrasonic)
Smiles
O=C1NC(N(CCC)C2=C1NC=N2)=O
Molecular Formula
C8H10N4O2
Molecular Weight
194.19
Precautions
H302, H312, H332
References & Citations
[1]I Feoktistov, et al. Adenosine A2b receptors evoke interleukin-8 secretion in human mast cells. An enprofylline-sensitive mechanism with implications for asthma. J Clin Invest. 1995 Oct;96 (4) :1979-86.|[2]M B Grant, et al. Proliferation, migration, and ERK activation in human retinal endothelial cells through A (2B) adenosine receptor stimulation. Invest Ophthalmol Vis Sci. 2001 Aug;42 (9) :2068-73.|[3]Jiang-Ning Yang, et al. Physiological roles of A1 and A2A adenosine receptors in regulating heart rate, body temperature, and locomotion as revealed using knockout mice and caffeine. Am J Physiol Heart Circ Physiol. 2009 Apr;296 (4) :H1141-9.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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